Kleoni Flessa was born in Kalamata. She studied photography in Boston and directing at the Stavrakos School. In 1978, she graduated from the Architecture School of the University of Florence. Additionally, she studied Film History at the Philosophy School of the University of Florence. She has directed numerous documentaries, music programs, and cultural shows for television.

1980 An everyday story
1983 Seaography
1995 Fron Sapphus to Kassiani
1999 Engonopoulos
1999 Embirikos
2002 Lets Go for Ouzo
2010 Eleni Mpoukouri Altamoura: the first Greek painter
2015 Nikolaos Dragoumis: a painter in the shadow of History
2022 My grandfather Papaflessas